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Angewandte Chemie (International Ed. in English)|January 19, 2017
A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red HerringJonathan Cramer, Johannes Schiebel, Tobias Wulsdorf, et al.
Biochemistry|February 24, 2015
An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reductionJohannes Schiebel, Andrew Chang, Benjamin Merget, et al.
ACS Infectious Diseases|March 12, 2021
A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop ClosureSandra Eltschkner, Josef Kehrein, Thien Anh Le, et al.
ACS Chemical Biology|March 31, 2016
Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case StudyJohannes Schiebel, Nedyalka Radeva, Stefan G Krimmer, et al.
Journal of Medicinal Chemistry|July 28, 2016
Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of EndothiapepsinNedyalka Radeva, Stefan G Krimmer, Martin Stieler, et al.
Structure (London, England : 1993)|July 26, 2016
High-Throughput Crystallography: Reliable and Efficient Identification of Fragment HitsJohannes Schiebel, Stefan G Krimmer, Karine Röwer, et al.
Journal of Medicinal Chemistry|October 12, 2016
Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic DyadNedyalka Radeva, Johannes Schiebel, Xiaojie Wang, et al.
Chemmedchem|August 12, 2015
One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit ListsJohannes Schiebel, Nedyalka Radeva, Helene Köster, et al.
The Journal of Biological Chemistry|April 18, 2014
Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitorJohannes Schiebel, Andrew Chang, Sonam Shah, et al.
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