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John A Christopher

Showing results (21-30 of 33) with videos related to

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Nature|December 8, 2016
Intracellular allosteric antagonism of the CCR9 receptorChristine Oswald, Mathieu Rappas, James Kean, et al.
Journal of Medicinal Chemistry|February 20, 2018
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>) X-ray StructuresJohn A Christopher, Zoltán Orgován, Miles Congreve, et al.
Journal of Medicinal Chemistry|July 31, 2015
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)John A Christopher, Sarah J Aves, Kirstie A Bennett, et al.
Bioorganic & Medicinal Chemistry Letters|March 25, 2011
3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-βDavid D Miller, Paul Bamborough, John A Christopher, et al.
Journal of Medicinal Chemistry|June 20, 2020
Structure-Based Drug Discovery of <i>N</i>-((<i>R</i>)-3-(7-Methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(((<i>S</i>)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-<i>d</i>][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of MigraineSarah J Bucknell, Mark A Ator, Alastair J H Brown, et al.
Journal of Medicinal Chemistry|April 8, 2009
Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta)John A Christopher, Paul Bamborough, Catherine Alder, et al.
Bioorganic & Medicinal Chemistry Letters|June 30, 2007
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokineticsPaul Bamborough, Richard M Angell, Inder Bhamra, et al.
Bioorganic & Medicinal Chemistry Letters|December 30, 2006
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3Richard M Angell, Francis L Atkinson, Murray J Brown, et al.
Bioorganic & Medicinal Chemistry Letters|May 16, 2007
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinasesJohn A Christopher, Barbara G Avitabile, Paul Bamborough, et al.
Journal of Medicinal Chemistry|December 21, 2019
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational AnalysisMathieu Rappas, Ammar A E Ali, Kirstie A Bennett, et al.
Pageof 4

Showing results (21-30 of 33) with videos related to

Sort By:
Pageof 4
Nature|December 8, 2016
Intracellular allosteric antagonism of the CCR9 receptorChristine Oswald, Mathieu Rappas, James Kean, et al.
Journal of Medicinal Chemistry|February 20, 2018
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu<sub>5</sub>) X-ray StructuresJohn A Christopher, Zoltán Orgován, Miles Congreve, et al.
Journal of Medicinal Chemistry|July 31, 2015
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)John A Christopher, Sarah J Aves, Kirstie A Bennett, et al.
Bioorganic & Medicinal Chemistry Letters|March 25, 2011
3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-βDavid D Miller, Paul Bamborough, John A Christopher, et al.
Journal of Medicinal Chemistry|June 20, 2020
Structure-Based Drug Discovery of <i>N</i>-((<i>R</i>)-3-(7-Methyl-1<i>H</i>-indazol-5-yl)-1-oxo-1-(((<i>S</i>)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-<i>d</i>][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of MigraineSarah J Bucknell, Mark A Ator, Alastair J H Brown, et al.
Journal of Medicinal Chemistry|April 8, 2009
Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta)John A Christopher, Paul Bamborough, Catherine Alder, et al.
Bioorganic & Medicinal Chemistry Letters|June 30, 2007
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokineticsPaul Bamborough, Richard M Angell, Inder Bhamra, et al.
Bioorganic & Medicinal Chemistry Letters|December 30, 2006
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3Richard M Angell, Francis L Atkinson, Murray J Brown, et al.
Bioorganic & Medicinal Chemistry Letters|May 16, 2007
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinasesJohn A Christopher, Barbara G Avitabile, Paul Bamborough, et al.
Journal of Medicinal Chemistry|December 21, 2019
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational AnalysisMathieu Rappas, Ammar A E Ali, Kirstie A Bennett, et al.
Pageof 4