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Journal of the American Chemical Society|April 2, 2009
Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligationCindy Kan, John D Trzupek, Bin Wu, et al.Organic Letters|October 21, 2015
Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated LactamsStephen W Wright, Chulho Choi, Seungwon Chung, et al.Medicinal Chemistry (Shariqah (United Arab Emirates))|June 23, 2006
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studiesJames L Toth, John D Trzupek, Lloyd V Flores, et al.Journal of the American Chemical Society|November 21, 2007
A unique class of duocarmycin and CC-1065 analogues subject to reductive activationWei Jin, John D Trzupek, Thomas J Rayl, et al.Journal of Medicinal Chemistry|October 26, 2012
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hitPaul V Fish, Panagis Filippakopoulos, Gerwyn Bish, et al.Science Advances|December 25, 2015
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenanceOleg Fedorov, Josefina Castex, Cynthia Tallant, et al.Journal of Medicinal Chemistry|April 27, 2016
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment HitBrian S Gerstenberger, John D Trzupek, Cynthia Tallant, et al.Journal of Medicinal Chemistry|January 4, 2018
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune DiseasesMichael L Vazquez, Neelu Kaila, Joseph W Strohbach, et al.Journal of Medicinal Chemistry|May 13, 2017
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug DesignKatherine L Lee, Catherine M Ambler, David R Anderson, et al.Journal of Medicinal Chemistry|August 22, 2018
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse AgonistMark E Schnute, Mattias Wennerstål, Jennifer Alley, et al.Pageof 2