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Molecular Oncology|February 15, 2011
High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097Wei He, Leopoldo Luistro, Daisy Carvajal, et al.Plos One|October 8, 2011
The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanomaChanh Huynh, Laura Poliseno, Miguel F Segura, et al.Molecular Therapy : the Journal of the American Society of Gene Therapy|September 5, 2013
Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capabilityWei He, Michael J Bennett, Leopoldo Luistro, et al.Journal of Medicinal Chemistry|August 30, 2021
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor ActivityJan Elsner, Dan Cashion, Dale Robinson, et al.Molecular Cancer Therapeutics|June 6, 2018
Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S CheckpointDan Zhu, Shuichan Xu, Gordafaried Deyanat-Yazdi, et al.Cancer Research|September 24, 2009
Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic propertiesLeopoldo Luistro, Wei He, Melissa Smith, et al.Bioorganic & Medicinal Chemistry Letters|December 17, 2011
Identification of novel, potent and selective inhibitors of Polo-like kinase 1Shaoqing Chen, David Bartkovitz, Jianping Cai, et al.Journal of Medicinal Chemistry|April 19, 2019
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent EfficacyJennifer R Riggs, Jan Elsner, Dan Cashion, et al.Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology|April 25, 2012
Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumorsAnthony W Tolcher, Wells A Messersmith, Stanislaw M Mikulski, et al.Journal of Medicinal Chemistry|November 15, 2002
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2)Eddy W Yue, C Anne Higley, Susan V DiMeo, et al.Pageof 3