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Biochemistry|September 24, 2024
Cocrystallization of the Src-Family Kinase Hck with the ATP-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop ConformationAri M Selzer, John J Alvarado, Thomas E Smithgall
The Journal of Biological Chemistry|September 3, 2010
Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanismJohn J Alvarado, Laurie Betts, Jamie A Moroco, et al.
Plos One|February 8, 2018
A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein bindingMousheng Wu, John J Alvarado, Corinne E Augelli-Szafran, et al.
Cell Reports|June 16, 2026
Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftmentGiancarlo Gonzalez-Areizaga, Sherry T Shu, John J Alvarado, et al.
Structure (London, England : 1993)|September 17, 2022
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, FgrShoucheng Du, John J Alvarado, Thomas E Wales, et al.
Cell Chemical Biology|March 20, 2024
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replicationLori A Emert-Sedlak, Colin M Tice, Haibin Shi, et al.
Biorxiv : the Preprint Server for Biology|August 30, 2023
PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 ReplicationLori A Emert-Sedlak, Colin M Tice, Haibin Shi, et al.
Science Signaling|September 20, 2022
The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interactionManish Aryal, David Lin, Kiera Regan, et al.
The Journal of Biological Chemistry|August 31, 2020
Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexesRyan P Staudt, John J Alvarado, Lori A Emert-Sedlak, et al.
Journal of Molecular Biology|February 11, 2023
Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid BilayersFrank Heinrich, Catherine E Thomas, John J Alvarado, et al.
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