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Molecular Cancer Therapeutics|October 3, 2019
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion MutationsPyoung Hwa Park, Tomomi M Yamamoto, Hua Li, et al.Nature Medicine|June 28, 2011
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibitionNeil Johnson, Yu-Chen Li, Zandra E Walton, et al.Cancer Research|February 18, 2021
Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End JoiningQin Zhou, Michelle E Howard, Xinyi Tu, et al.Nature Communications|July 26, 2020
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer modelsHyoung Kim, Haineng Xu, Erin George, et al.Journal of Aerosol Medicine and Pulmonary Drug Delivery|February 10, 2016
Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose PredictionsMichael Caniga, Antonio Cabal, Khamir Mehta, et al.Proceedings of the National Academy of Sciences of the United States of America|October 3, 2013
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistanceNeil Johnson, Shawn F Johnson, Wei Yao, et al.Journal of Medicinal Chemistry|October 22, 2025
RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant TumorsGurushankar Chandramouly, William Fried, John Gordon, et al.Cell Reports|June 14, 2018
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor CellsKatherine Sullivan-Reed, Elisabeth Bolton-Gillespie, Yashodhara Dasgupta, et al.JCI Insight|January 19, 2017
A patient-derived-xenograft platform to study BRCA-deficient ovarian cancersErin George, Hyoung Kim, Clemens Krepler, et al.Molecular Cell|August 1, 2025
PALB2 and 53BP1 govern post-resection homologous recombination DNA repairYifan Wang, Yan Coulombe, Wei-Ting Yueh, et al.Pageof 14