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Bioorganic & Medicinal Chemistry Letters|June 1, 2010
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonistsJeffrey Y Melamed, Amy E Zartman, Nathan R Kett, et al.Chemmedchem|September 15, 2011
Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3)Craig A Coburn, Yunfu Luo, Mingxiang Cui, et al.BMC Neuroscience|August 29, 2013
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy thresholdAnthony L Gotter, Christopher J Winrow, Joseph Brunner, et al.Scientific Reports|June 4, 2016
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to ManAnthony L Gotter, Mark S Forman, Charles M Harrell, et al.Bioorganic & Medicinal Chemistry Letters|November 26, 2015
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, John D Schreier, Joy Fuerst, et al.Bioorganic & Medicinal Chemistry Letters|January 12, 2015
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexantIzzat T Raheem, Michael J Breslin, Joseph Bruno, et al.Bioorganic & Medicinal Chemistry Letters|August 3, 2010
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonistsKelly-Ann S Schlegel, Zhi-Qiang Yang, Thomas S Reger, et al.Bioorganic & Medicinal Chemistry Letters|February 15, 2011
Pyridyl amides as potent inhibitors of T-type calcium channelsThomas S Reger, Zhi-Qiang Yang, Kelly-Ann S Schlegel, et al.Science Translational Medicine|April 5, 2013
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognitionJason M Uslaner, Spencer J Tye, Donnie M Eddins, et al.Chemmedchem|May 7, 2009
Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in ratsDavid B Whitman, Christopher D Cox, Michael J Breslin, et al.Pageof 12