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Journal of Neurogenetics|April 9, 2011
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonistChristopher J Winrow, Anthony L Gotter, Christopher D Cox, et al.Bioorganic & Medicinal Chemistry Letters|March 18, 2014
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexantScott D Kuduk, Jason W Skudlarek, Christina N Di Marco, et al.Neuropharmacology|July 4, 2012
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkeySean M Smith, Jason M Uslaner, Christopher D Cox, et al.Bioorganic & Medicinal Chemistry Letters|August 16, 2012
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, Michael J Breslin, Christine Fandozzi, et al.Neuropharmacology|October 25, 2011
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomniaChristopher J Winrow, Anthony L Gotter, Christopher D Cox, et al.Neuron|March 31, 2005
Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortexPhilip E Brandish, Ming Su, Daniel J Holder, et al.Neuropharmacology|July 15, 2009
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposureChristopher J Winrow, Keith Q Tanis, Duane R Reiss, et al.Bioorganic & Medicinal Chemistry Letters|June 17, 2015
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitorsChristopher D Cox, Eric D Hostetler, Broc A Flores, et al.Bioorganic & Medicinal Chemistry Letters|July 9, 2010
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the ratPaul J Coleman, John D Schreier, Anthony J Roecker, et al.Bioorganic & Medicinal Chemistry Letters|April 24, 2016
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitorsThomas J Greshock, John M Sanders, Robert E Drolet, et al.Pageof 12