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Journal of Medicinal Chemistry|May 9, 2013
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligandLei Zhang, Anabella Villalobos, Elizabeth M Beck, et al.Bioorganic & Medicinal Chemistry Letters|January 14, 2015
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilinMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Annals of Internal Medicine|November 29, 2021
Disparities in Dolutegravir Uptake Affecting Females of Reproductive Age With HIV in Low- and Middle-Income Countries After Initial Concerns About Teratogenicity : An Observational StudyMatthew L Romo, Rena C Patel, Jessie K Edwards, et al.Journal of Medicinal Chemistry|June 10, 2011
Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophreniaChristopher J Helal, Zhijun Kang, Xinjun Hou, et al.Journal of Medicinal Chemistry|September 29, 2017
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) ImagingLei Zhang, Laigao Chen, Elizabeth M Beck, et al.Cell Chemical Biology|September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoEUthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.Medchemcomm|August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacyMartin Pettersson, Douglas S Johnson, Danica A Rankic, et al.ACS Medicinal Chemistry Letters|May 26, 2015
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic StabilityMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Journal of Medicinal Chemistry|June 3, 2017
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A InhibitorChristopher J Helal, Eric P Arnold, Tracey L Boyden, et al.Journal of Medicinal Chemistry|January 3, 2018
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical CandidateChristopher J Helal, Eric Arnold, Tracey Boyden, et al.Pageof 6