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John R Atack

Showing results (71-80 of 97) with videos related to

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Journal of Medicinal Chemistry|August 6, 2025
Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK InhibitorsAlex G Baldwin, David W Foley, D Heulyn Jones, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|July 5, 2002
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptorNeil Collinson, Frederick M Kuenzi, Wolfgang Jarolimek, et al.
Bioorganic & Medicinal Chemistry Letters|June 5, 2004
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptorAndrew Mitchinson, John R Atack, Peter Blurton, et al.
Psychopharmacology|December 3, 2009
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptorJames R Shoblock, Natalie Welty, Diane Nepomuceno, et al.
Journal of Medicinal Chemistry|April 19, 2002
3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channelsIan Collins, Christopher Moyes, William B Davey, et al.
Journal of Psychopharmacology (Oxford, England)|November 10, 2006
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligandsRosa L Fradley, Martin R Guscott, Sharlene Bull, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 27, 2005
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primatesJohn R Atack, Keith A Wafford, Spencer J Tye, et al.
The Journal of Pharmacology and Experimental Therapeutics|June 15, 2013
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782Hilde Lavreysen, Xavier Langlois, Abdel Ahnaou, et al.
ACS Chemical Neuroscience|September 10, 2014
JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's diseaseJohn R Atack, Brian C Shook, Stefanie Rassnick, et al.
The Biochemical Journal|April 22, 2016
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2Peter Hornyak, Trevor Askwith, Sarah Walker, et al.
Pageof 10

Showing results (71-80 of 97) with videos related to

Sort By:
Pageof 10
Journal of Medicinal Chemistry|August 6, 2025
Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK InhibitorsAlex G Baldwin, David W Foley, D Heulyn Jones, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|July 5, 2002
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptorNeil Collinson, Frederick M Kuenzi, Wolfgang Jarolimek, et al.
Bioorganic & Medicinal Chemistry Letters|June 5, 2004
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptorAndrew Mitchinson, John R Atack, Peter Blurton, et al.
Psychopharmacology|December 3, 2009
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptorJames R Shoblock, Natalie Welty, Diane Nepomuceno, et al.
Journal of Medicinal Chemistry|April 19, 2002
3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channelsIan Collins, Christopher Moyes, William B Davey, et al.
Journal of Psychopharmacology (Oxford, England)|November 10, 2006
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligandsRosa L Fradley, Martin R Guscott, Sharlene Bull, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 27, 2005
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primatesJohn R Atack, Keith A Wafford, Spencer J Tye, et al.
The Journal of Pharmacology and Experimental Therapeutics|June 15, 2013
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782Hilde Lavreysen, Xavier Langlois, Abdel Ahnaou, et al.
ACS Chemical Neuroscience|September 10, 2014
JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's diseaseJohn R Atack, Brian C Shook, Stefanie Rassnick, et al.
The Biochemical Journal|April 22, 2016
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2Peter Hornyak, Trevor Askwith, Sarah Walker, et al.
Pageof 10