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The Biochemical Journal|April 28, 2023
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinaseCatia L Pierotti, Annette V Jacobsen, Christoph Grohmann, et al.
Elife|December 25, 2015
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1Nima Etemadi, Michael Chopin, Holly Anderton, et al.
Cell Death and Differentiation|February 9, 2023
MLKL deficiency protects against low-grade, sterile inflammation in aged miceEmma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, et al.
Cell Reports|September 12, 2017
The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid TissuesAjithkumar Vasanthakumar, Yang Liao, Peggy Teh, et al.
Nature Communications|February 19, 2015
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKLKate E Lawlor, Nufail Khan, Alison Mildenhall, et al.
Cell Reports|November 29, 2018
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β ActivationJames E Vince, Dominic De Nardo, Wenqing Gao, et al.
Blood|October 29, 2024
Venetoclax dose escalation rapidly activates a BAFF/BCL-2 survival axis in chronic lymphocytic leukemiaMeng-Xiao Luo, Tania Tan, Marie Trussart, et al.
Immunity|August 1, 2020
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular InfectionMarcel Doerflinger, Yexuan Deng, Paul Whitney, et al.
Cancer Discovery|October 25, 2023
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer CellsZilu Wang, Matteo Burigotto, Sabrina Ghetti, et al.
Nature Communications|June 23, 2018
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosisEmma J Petrie, Jarrod J Sandow, Annette V Jacobsen, et al.
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