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Nature Communications|April 20, 2022
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platformsChristoph Grohmann, Charlene M Magtoto, Joel R Walker, et al.
Elife|December 3, 2014
TNFR1-dependent cell death drives inflammation in Sharpin-deficient miceJames A Rickard, Holly Anderton, Nima Etemadi, et al.
Nature Communications|June 10, 2026
Infection-induced glucose starvation triggers NINJ1-dependent macrophage lysis and Candida escapeHarshini Weerasinghe, Orawan Tulyaprawat, Helen Stölting, et al.
Science Translational Medicine|May 20, 2016
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemiaGabriela Brumatti, Chunyan Ma, Najoua Lalaoui, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 8, 2014
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell deathJoanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, et al.
Communications Chemistry|January 19, 2026
Expanding the toolbox to develop IAP-based degraders of TEAD transcription factorsNishma Gupta, Nicole Trainor, Mona Radwan, et al.
Blood|February 14, 2019
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemiaHelen M McRae, Alexandra L Garnham, Yifang Hu, et al.
Molecular Cell|January 2, 2019
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and InflammationGianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, et al.
ACS Chemical Biology|September 9, 2020
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the PathwayCatia L Pierotti, Maria C Tanzer, Annette V Jacobsen, et al.
Nature Microbiology|January 14, 2017
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammationJaclyn S Pearson, Cristina Giogha, Sabrina Mühlen, et al.
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