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Nature Communications|August 21, 2025
Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphomaMargaret A Potts, Shinsuke Mizutani, Yexuan Deng, et al.Blood Advances|October 20, 2020
Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML modelsEmma Morrish, Anthony Copeland, Donia M Moujalled, et al.Nature Communications|September 11, 2020
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeuticallyEnkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, et al.Nature Communications|June 21, 2020
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosisAndre L Samson, Ying Zhang, Niall D Geoghegan, et al.Cell|September 12, 2015
Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs SurvivalAmelia J Johnston, Kate T Murphy, Laura Jenkinson, et al.Blood|April 7, 2021
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemiasRachel Thijssen, Sarah T Diepstraten, Donia Moujalled, et al.Nature Communications|November 13, 2025
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infectionStefanie M Bader, Lena Scherer, Reet Bhandari, et al.Nature Communications|March 18, 2015
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine productionUeli Nachbur, Che A Stafford, Aleksandra Bankovacki, et al.The EMBO Journal|January 17, 2023
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiencySebastian A Hughes, Meng Lin, Ashley Weir, et al.Journal of Medicinal Chemistry|April 2, 2014
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignanciesStephen M Condon, Yasuhiro Mitsuuchi, Yijun Deng, et al.Pageof 46