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Bioorganic & Medicinal Chemistry Letters|May 20, 2015
Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utilityTimothy Senter, Rocco D Gogliotti, Changho Han, et al.Cancer Research|August 6, 2013
Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cellsAlexander Sio, Manreet K Chehal, Kevin Tsai, et al.Proceedings of the National Academy of Sciences of the United States of America|May 17, 2008
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expressionFrank E Erfurth, Relja Popovic, Jolanta Grembecka, et al.Science Advances|June 17, 2021
Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancerChunhua Wan, Sylvia Mahara, Claire Sun, et al.Combinatorial Chemistry & High Throughput Screening|January 14, 2014
The role of HTS in drug discovery at the University of MichiganMartha J Larsen, Scott D Larsen, Andrew Fribley, et al.Journal of Medicinal Chemistry|January 9, 2016
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Dmitry Borkin, Jonathan Pollock, Katarzyna Kempinska, et al.Journal of Medicinal Chemistry|May 9, 2018
Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia InteractionDmitry Borkin, Szymon Klossowski, Jonathan Pollock, et al.The Journal of Clinical Investigation|April 14, 2015
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cellsMorgan Jones, Jennifer Chase, Michelle Brinkmeier, et al.Journal of Medicinal Chemistry|January 30, 2014
High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interactionShihan He, Timothy J Senter, Jonathan Pollock, et al.Cell Chemical Biology|July 21, 2021
Development of potent dimeric inhibitors of GAS41 YEATS domainDymytrii Listunov, Brian M Linhares, EunGi Kim, et al.Pageof 8