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Trends in Pharmacological Sciences|June 1, 2014
Biased ligands at G-protein-coupled receptors: promise and progressJonathan D Violin, Aimee L Crombie, David G Soergel, et al.Current Opinion in Pharmacology|May 20, 2014
Biased ligands: pathway validation for novel GPCR therapeuticsDavid H Rominger, Conrad L Cowan, William Gowen-MacDonald, et al.Trends in Cardiovascular Medicine|March 19, 2013
GPCR biased ligands as novel heart failure therapeuticsJonathan D Violin, David G Soergel, Guido Boerrigter, et al.Chemistry & Biology|March 18, 2014
Intramolecular conformational changes optimize protein kinase C signalingCorina E Antal, Jonathan D Violin, Maya T Kunkel, et al.Circulation. Heart Failure|August 15, 2012
TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failureGuido Boerrigter, David G Soergel, Jonathan D Violin, et al.The Journal of Biological Chemistry|June 11, 2009
beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signalingDouglas G Tilley, Il-Man Kim, Priyesh A Patel, et al.Journal of Clinical Pharmacology|July 2, 2013
First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteersDavid G Soergel, Ruth Ann Subach, Conrad L Cowan, et al.American Journal of Physiology. Heart and Circulatory Physiology|August 14, 2012
β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injuryKi-Seok Kim, Dennis Abraham, Barbara Williams, et al.The Journal of Biological Chemistry|December 22, 2004
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulationWilliam G Barnes, Eric Reiter, Jonathan D Violin, et al.The Journal of Biological Chemistry|November 30, 2007
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamicsJonathan D Violin, Lisa M DiPilato, Necmettin Yildirim, et al.Pageof 5