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Molecular Pharmacology|January 7, 2005
Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxisDacia L Hunton, William G Barnes, Jihee Kim, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 24, 2017
TRV0109101, a G Protein-Biased Agonist of the <i>µ</i>-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic AdministrationMichael Koblish, Richard Carr, Edward R Siuda, et al.
Pain|June 24, 2014
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteersDavid G Soergel, Ruth Ann Subach, Nancy Burnham, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 25, 2006
Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytesKeshava Rajagopal, Erin J Whalen, Jonathan D Violin, et al.
Cardiovascular Research|June 6, 2015
Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy modelMadhusudhan Tarigopula, Robert T Davis, Paul T Mungai, et al.
The Journal of Biological Chemistry|March 27, 2014
Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Ryan T Strachan, Jin-peng Sun, David H Rominger, et al.
Molecular Pharmacology|June 6, 2008
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensorLarry S Barak, Ali Salahpour, Xiaodong Zhang, et al.
The Journal of Clinical Investigation|September 6, 2007
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotectionTakahisa Noma, Anthony Lemaire, Sathyamangla V Naga Prasad, et al.
The Journal of Clinical Investigation|April 8, 2009
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in miceRobert W Walters, Arun K Shukla, Jeffrey J Kovacs, et al.
Journal of Medicinal Chemistry|September 26, 2013
Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe painXiao-Tao Chen, Philip Pitis, Guodong Liu, et al.
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