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Nature Communications|February 11, 2023
Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing systemWei Huang, Hongyun Li, Janna Kiselar, et al.Antiviral Research|January 3, 2018
A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replicationPriya Luthra, Jue Liang, Colette A Pietzsch, et al.Journal of Medicinal Chemistry|April 5, 2014
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike propertiesJacinth Naidoo, Hector De Jesus-Cortes, Paula Huntington, et al.Cell Stem Cell|January 29, 2022
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regenerationYuemeng Jia, Lin Li, Yu-Hsuan Lin, et al.Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation|May 19, 2020
Inhibition of 15-PGDH Protects Mice from Immune-Mediated Bone Marrow FailureJulianne N P Smith, Folashade Otegbeye, Alvin P Jogasuria, et al.Cell|April 6, 2022
A male-derived nonribosomal peptide pheromone controls female schistosome developmentRui Chen, Jipeng Wang, Irina Gradinaru, et al.The Journal of Biological Chemistry|March 6, 2025
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteineGenaro Hernandez, Adam Osinski, Abir Majumdar, et al.Antiviral Research|August 26, 2018
Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responsesPriya Luthra, Jacinth Naidoo, Colette A Pietzsch, et al.Journal of Medicinal Chemistry|August 14, 2020
Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA DesaturaseNoelle S Williams, Stephen Gonzales, Jacinth Naidoo, et al.JCI Insight|February 18, 2021
15-PGDH inhibition activates the splenic niche to promote hematopoietic regenerationJulianne Np Smith, Dawn M Dawson, Kelsey F Christo, et al.Pageof 9