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ACS Chemical Biology|June 3, 2024
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve CancersPanayotis C Theodoropoulos, Holly H Guo, Wentian Wang, et al.
Journal of Medicinal Chemistry|November 2, 2022
Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and RegenerationBin Hu, Kosuke Toda, Xiaoyu Wang, et al.
Nature Communications|July 20, 2024
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiencyRachel Tesla, Charlotte Guhl, Gordon C Werthmann, et al.
NPJ Parkinson'S Disease|May 10, 2016
Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's diseaseHéctor De Jesús-Cortés, Adam D Miller, Jeremiah K Britt, et al.
Journal of the American Chemical Society|January 8, 2011
Development of proneurogenic, neuroprotective small moleculesKaren S MacMillan, Jacinth Naidoo, Jue Liang, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 3, 2012
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosisRachel Tesla, Hamilton Parker Wolf, Pin Xu, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 3, 2012
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson diseaseHéctor De Jesús-Cortés, Pin Xu, Jordan Drawbridge, et al.
Nature Chemical Biology|November 25, 2025
SINE compounds activate exportin 1 degradation through an allosteric mechanismCasey E Wing, Ho Yee Joyce Fung, Bert Kwanten, et al.
The EMBO Journal|January 4, 2026
Bacterial ubiquitin ligase engineered for small molecule and protein target identificationJames S Ye, Abir Majumdar, Brenden C Park, et al.
ACS Infectious Diseases|February 10, 2023
Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL)Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, et al.
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