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Science Advances|May 4, 2019
cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing TregsJoanna Z Kawalkowska, Joy Ogbechi, Patrick J Venables, et al.
Frontiers in Immunology|March 21, 2020
IDO and Kynurenine Metabolites in Peripheral and CNS DisordersYi-Shu Huang, Joy Ogbechi, Felix I Clanchy, et al.
Experimental Gerontology|December 30, 2019
IDO activation, inflammation and musculoskeletal diseaseJoy Ogbechi, Felix I Clanchy, Yi-Shu Huang, et al.
Plos Pathogens|April 5, 2014
The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ERBelinda S Hall, Kirsti Hill, Michael McKenna, et al.
Frontiers in Immunology|April 4, 2022
Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?Felix I L Clanchy, Yi-Shu Huang, Joy Ogbechi, et al.
Cell Death & Disease|March 16, 2018
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4Joy Ogbechi, Belinda S Hall, Thomas Sbarrato, et al.
Frontiers in Immunology|November 17, 2022
Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)Joy Ogbechi, Yi-Shu Huang, Felix I L Clanchy, et al.
The Biochemical Journal|November 2, 2021
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable statePratiti Bhadra, Scott Dos Santos, Igor Gamayun, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 11, 2019
TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cellsWen-Yi Tseng, Yi-Shu Huang, Felix Clanchy, et al.
Plos Pathogens|January 31, 2022
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesionsLouise Tzung-Harn Hsieh, Scott J Dos Santos, Belinda S Hall, et al.
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