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Cancer Chemotherapy and Pharmacology|October 25, 2022
Absorption, distribution, metabolism, and excretion of [14C]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in ratsXin-Mei Li, Yuan-Dong Zheng, Yi-Fan Zhang, et al.
International Journal of Cancer|January 25, 2019
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicityHua-Dong Chen, Chuan-Huizi Chen, Yu-Ting Wang, et al.
Nature Communications|March 15, 2025
USP7 V517F mutation as a mechanism of inhibitor resistanceYu-Ling Miao, Fengying Fan, Yong-Jun Cheng, et al.
Acta Pharmacologica Sinica|August 4, 2017
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacyWen-Hua Chen, Shan-Shan Song, Ming-Hui Qi, et al.
Life Sciences|February 27, 2025
The combination of BET and METTL3 inhibitors elicits synergistic antitumor effects in ovarian cancer cells via reducing SP1 and BCL-2 expressionYing-Jie Ou, Ben-Jin Liu, Yi-Fei Xuan, et al.
Neoplasia (New York, N.Y.)|July 30, 2022
SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapyLi-Na Zhou, Chaodong Xiong, Yong-Jun Cheng, et al.
Biochemical Pharmacology|February 4, 2021
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1Qian Wu, Dan-Qi Chen, Lin Sun, et al.
Molecular Cancer Therapeutics|April 2, 2014
MCL-1 degradation mediated by JNK activation via MEKK1/TAK1-MKK4 contributes to anticancer activity of new tubulin inhibitor MT189Wei Wang, Ying-Qing Wang, Tao Meng, et al.
European Journal of Medicinal Chemistry|June 18, 2024
Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7(8H)-one derivatives as potent USP1 inhibitorsHongrui Li, Ben-Jin Liu, Jiahao Xu, et al.
Marine Drugs|January 19, 2019
Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa, Phyllidia coelestis, and Their Sponge-Prey Acanthella cavernosaQihao Wu, Wen-Ting Chen, Song-Wei Li, et al.
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