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Journal of Medicinal Chemistry|August 20, 2011
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallographyStephen Patterson, Magnus S Alphey, Deuan C Jones, et al.
Cell Chemical Biology|August 8, 2017
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-AminesNicola J Gardner, Peter J Gillespie, Jamie T Carrington, et al.
Chemmedchem|November 20, 2009
Investigation of trypanothione reductase as a drug target in Trypanosoma bruceiDaniel Spinks, Emma J Shanks, Laura A T Cleghorn, et al.
The Journal of Biological Chemistry|October 16, 2009
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasisLeah S Torrie, Susan Wyllie, Daniel Spinks, et al.
Chemmedchem|June 19, 2013
From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead moleculesAndrew Woodland, Raffaella Grimaldi, Torsten Luksch, et al.
Bioorganic & Medicinal Chemistry|January 24, 2012
Quinol derivatives as potential trypanocidal agentsAmy Capes, Stephen Patterson, Susan Wyllie, et al.
Malaria Journal|November 9, 2017
Screening a protein kinase inhibitor library against Plasmodium falciparumIrene Hallyburton, Raffaella Grimaldi, Andrew Woodland, et al.
Antimicrobial Agents and Chemotherapy|April 11, 2013
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assayManu De Rycker, Irene Hallyburton, John Thomas, et al.
ACS Chemical Biology|July 10, 2013
A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma bruceiMichael D Urbaniak, Iain T Collie, Wenxia Fang, et al.
Chemmedchem|January 29, 2011
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1Daniel Spinks, Han B Ong, Chidochangu P Mpamhanga, et al.
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