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Justin Ly

Showing results (31-40 of 39) with videos related to

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Journal of Medicinal Chemistry|July 18, 2013
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitorsXiaozhang Zheng, Paul Bauer, Timm Baumeister, et al.
Bioorganic & Medicinal Chemistry Letters|October 22, 2013
Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)Colin H MacKinnon, Kevin Lau, Jason D Burch, et al.
Bioorganic & Medicinal Chemistry Letters|January 4, 2015
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubilityMark Zak, Bianca M Liederer, Deepak Sampath, et al.
Journal of Medicinal Chemistry|October 24, 2022
Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 InhibitorChristopher McBride, Lynnie Trzoss, Davide Povero, et al.
Journal of Medicinal Chemistry|February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple MyelomaXiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.
Bioorganic & Medicinal Chemistry Letters|September 12, 2013
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)Xiaozhang Zheng, Kenneth W Bair, Paul Bauer, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 3, 2019
Disruption of IRE1α through its kinase domain attenuates multiple myelomaJonathan M Harnoss, Adrien Le Thomas, Anna Shemorry, et al.
Journal of Medicinal Chemistry|September 30, 2016
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300Terry D Crawford, F Anthony Romero, Kwong Wah Lai, et al.
Journal of Medicinal Chemistry|September 12, 2017
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)F Anthony Romero, Jeremy Murray, Kwong Wah Lai, et al.
Pageof 4

Showing results (31-40 of 39) with videos related to

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Pageof 4
You have reached the last page of results.This site can display upto 39 results.
Journal of Medicinal Chemistry|July 18, 2013
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitorsXiaozhang Zheng, Paul Bauer, Timm Baumeister, et al.
Bioorganic & Medicinal Chemistry Letters|October 22, 2013
Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)Colin H MacKinnon, Kevin Lau, Jason D Burch, et al.
Bioorganic & Medicinal Chemistry Letters|January 4, 2015
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubilityMark Zak, Bianca M Liederer, Deepak Sampath, et al.
Journal of Medicinal Chemistry|October 24, 2022
Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 InhibitorChristopher McBride, Lynnie Trzoss, Davide Povero, et al.
Journal of Medicinal Chemistry|February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple MyelomaXiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.
Bioorganic & Medicinal Chemistry Letters|September 12, 2013
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)Xiaozhang Zheng, Kenneth W Bair, Paul Bauer, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 3, 2019
Disruption of IRE1α through its kinase domain attenuates multiple myelomaJonathan M Harnoss, Adrien Le Thomas, Anna Shemorry, et al.
Journal of Medicinal Chemistry|September 30, 2016
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300Terry D Crawford, F Anthony Romero, Kwong Wah Lai, et al.
Journal of Medicinal Chemistry|September 12, 2017
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)F Anthony Romero, Jeremy Murray, Kwong Wah Lai, et al.
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