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Topics in Current Chemistry|June 8, 2011
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitorsDaniel F Wyss, Yu-Sen Wang, Hugh L Eaton, et al.Journal of Medicinal Chemistry|April 30, 2004
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screeningDaniel F Wyss, Ashok Arasappan, Mary M Senior, et al.Journal of Biomolecular Screening|March 31, 2016
NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaAYan Hou, Todd Mayhood, Payal Sheth, et al.Nature Communications|January 3, 2026
WRN structural flexibility showcased through fragment-based lead discovery of inhibitorsRachel L Palte, Mihir Mandal, Justyna Sikorska, et al.Biochemical Pharmacology|December 17, 2014
Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin AJeffrey D Serrill, Michelle Tan, Serge Fotso, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B PolymeraseCliff C Cheng, Xiaohua Huang, Gerald W Shipps, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) InhibitorsXiaohua Huang, Gerald W Shipps, Cliff C Cheng, et al.Journal of Medicinal Chemistry|January 2, 2010
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitorsYu-Sen Wang, Corey Strickland, Johannes H Voigt, et al.Journal of Medicinal Chemistry|January 2, 2010
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validationZhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, et al.Journal of Medicinal Chemistry|March 25, 2022
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of CancerWonsuk Chang, Michael D Altman, Charles A Lesburg, et al.Pageof 5