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The Journal of Biological Chemistry|October 26, 2000
Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosisK A Browne, R W Johnstone, D A Jans, et al.Journal of Immunology (Baltimore, Md. : 1950)|March 11, 1999
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independentJ Bondeson, K A Browne, F M Brennan, et al.The Journal of Biological Chemistry|July 15, 1994
Granule serine proteases are normal nuclear constituents of natural killer cellsJ A Trapani, M J Smyth, V A Apostolidis, et al.Journal of Leukocyte Biology|January 1, 1995
Distinct granzyme expression in human CD3- CD56+ large granular- and CD3- CD56+ small high density-lymphocytes displaying non-MHC-restricted cytolytic activityM J Smyth, K A Browne, B F Kinnear, et al.Immunology and Cell Biology|April 2, 1999
Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis inductionK M Edwards, J E Davis, K A Browne, et al.British Journal of Rheumatology|June 1, 1997
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapyF M Brennan, K A Browne, P A Green, et al.Molecular and Cellular Biology|November 24, 1999
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforinK A Browne, E Blink, V R Sutton, et al.Clinical and Experimental Pharmacology & Physiology|January 1, 1994
Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosisM J Smyth, K A Browne, K Y Thia, et al.The Journal of Biological Chemistry|October 17, 1998
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independentJ A Trapani, D A Jans, P J Jans, et al.Journal of Leukocyte Biology|July 4, 2001
Unlocking the secrets of cytotoxic granule proteinsM J Smyth, J M Kelly, V R Sutton, et al.Pageof 3