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European Journal of Medicinal Chemistry|August 15, 2021
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasisEhab Ghazy, Tino Heimburg, Julien Lancelot, et al.Journal of Medicinal Chemistry|December 1, 2017
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma ActivityTino Heimburg, Fiona R Kolbinger, Patrik Zeyen, et al.European Journal of Medicinal Chemistry|November 17, 2020
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigationNicola Relitti, A Prasanth Saraswati, Giulia Chemi, et al.Future Medicinal Chemistry|August 31, 2016
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1)Dmytro Ostrovskyi, Tobias Rumpf, Julia Eib, et al.Plos Pathogens|October 3, 2013
Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoniMartin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, et al.Journal of Medicinal Chemistry|October 23, 2018
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional DeterminantsMartin Marek, Tajith B Shaik, Tino Heimburg, et al.Nature Communications|February 13, 2015
Selective Sirt2 inhibition by ligand-induced rearrangement of the active siteTobias Rumpf, Matthias Schiedel, Berin Karaman, et al.Chembiochem : a European Journal of Chemical Biology|May 24, 2022
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target EngagementDaniel Herp, Johannes Ridinger, Dina Robaa, et al.Chemmedchem|November 15, 2014
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease modelPaolo Di Fruscia, Emmanouil Zacharioudakis, Chang Liu, et al.Cell Reports|December 22, 2021
Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, et al.Pageof 3