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Karla Frydenvang

Showing results (71-80 of 81) with videos related to

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Journal of Medicinal Chemistry|December 20, 2017
7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar PotencyEric Goffin, Thomas Drapier, Anja Probst Larsen, et al.
Journal of Medicinal Chemistry|May 31, 2011
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterizationRaminta Venskutonyte, Stefania Butini, Salvatore Sanna Coccone, et al.
European Journal of Medicinal Chemistry|December 15, 2023
Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulatorsPierre Francotte, Yasmin Bay, Eric Goffin, et al.
Journal of Medicinal Chemistry|December 23, 2016
Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic AcidNiels Krogsgaard-Larsen, Claudia G Delgar, Karina Koch, et al.
Journal of Medicinal Chemistry|May 24, 2019
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA TransportersAlessandro Giraudo, Jacob Krall, Francesco Bavo, et al.
ACS Medicinal Chemistry Letters|August 14, 2024
AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer ApplicationsAgnese C Pippione, Chiara Vigato, Cristina Tucciarello, et al.
ACS Chemical Neuroscience|October 18, 2019
<i>N</i>-(7-(1<i>H</i>-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2<i>H</i>)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo PharmacologyStine Møllerud, Rie B Hansen, Jakob Pallesen, et al.
Journal of Medicinal Chemistry|February 17, 2018
( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological InvestigationSimone Brogi, Margherita Brindisi, Stefania Butini, et al.
Journal of Medicinal Chemistry|November 7, 2014
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxidesPierre Francotte, Ann-Beth Nørholm, Taru Deva, et al.
Neuron|May 5, 2019
Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA ReceptorsG Brent Dawe, Md Fahim Kadir, Raminta Venskutonytė, et al.
Pageof 9

Showing results (71-80 of 81) with videos related to

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Pageof 9
Journal of Medicinal Chemistry|December 20, 2017
7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar PotencyEric Goffin, Thomas Drapier, Anja Probst Larsen, et al.
Journal of Medicinal Chemistry|May 31, 2011
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterizationRaminta Venskutonyte, Stefania Butini, Salvatore Sanna Coccone, et al.
European Journal of Medicinal Chemistry|December 15, 2023
Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulatorsPierre Francotte, Yasmin Bay, Eric Goffin, et al.
Journal of Medicinal Chemistry|December 23, 2016
Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic AcidNiels Krogsgaard-Larsen, Claudia G Delgar, Karina Koch, et al.
Journal of Medicinal Chemistry|May 24, 2019
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA TransportersAlessandro Giraudo, Jacob Krall, Francesco Bavo, et al.
ACS Medicinal Chemistry Letters|August 14, 2024
AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer ApplicationsAgnese C Pippione, Chiara Vigato, Cristina Tucciarello, et al.
ACS Chemical Neuroscience|October 18, 2019
<i>N</i>-(7-(1<i>H</i>-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2<i>H</i>)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo PharmacologyStine Møllerud, Rie B Hansen, Jakob Pallesen, et al.
Journal of Medicinal Chemistry|February 17, 2018
( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological InvestigationSimone Brogi, Margherita Brindisi, Stefania Butini, et al.
Journal of Medicinal Chemistry|November 7, 2014
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxidesPierre Francotte, Ann-Beth Nørholm, Taru Deva, et al.
Neuron|May 5, 2019
Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA ReceptorsG Brent Dawe, Md Fahim Kadir, Raminta Venskutonytė, et al.
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