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Blood|November 16, 2014
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibitionAndrew Kernytsky, Fang Wang, Erica Hansen, et al.The Oncologist|April 25, 2014
Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarateAmir T Fathi, Hossein Sadrzadeh, Amy H Comander, et al.Blood|June 8, 2017
Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical responseMichael D Amatangelo, Lynn Quek, Alan Shih, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in VivoJaneta Popovici-Muller, Jeffrey O Saunders, Francesco G Salituro, et al.Genes & Development|August 29, 2012
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane functionMasato Sasaki, Christiane B Knobbe, Momoe Itsumi, et al.Journal of Medicinal Chemistry|February 9, 2026
Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of CancerJames Neef, Kimberly S Straley, Chinmoy Mukherjee, et al.Journal of Neuro-Oncology|October 22, 2011
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopyWhitney B Pope, Robert M Prins, M Albert Thomas, et al.Blood|October 18, 2012
Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic responseAmir T Fathi, Hossein Sadrzadeh, Darrell R Borger, et al.Nature|November 26, 2009
Cancer-associated IDH1 mutations produce 2-hydroxyglutarateLenny Dang, David W White, Stefan Gross, et al.Science (New York, N.Y.)|April 6, 2013
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cellsDan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, et al.Pageof 2