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Biochimica Et Biophysica Acta|May 27, 2014
Targeting histone lysine demethylases - progress, challenges, and the futureCyrille C Thinnes, Katherine S England, Akane Kawamura, et al.Journal of Medicinal Chemistry|December 29, 2015
Recent Progress in Histone Demethylase InhibitorsTom E McAllister, Katherine S England, Richard J Hopkinson, et al.Medchemcomm|December 19, 2015
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitorKatherine S England, Anthony Tumber, Tobias Krojer, et al.Molecular & Cellular Proteomics : MCP|June 29, 2023
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule BenzosulfonamidesDarragh P O'Brien, Hannah B L Jones, Franziska Guenther, et al.Journal of Proteome Research|January 13, 2025
Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent InhibitorDarragh P O'Brien, Hannah B L Jones, Yuqi Shi, et al.Bioorganic & Medicinal Chemistry Letters|September 20, 2011
Acidic triazoles as soluble guanylate cyclase stimulatorsLee R Roberts, Paul A Bradley, Mark E Bunnage, et al.Journal of Medicinal Chemistry|December 17, 2016
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and SkinPeter Jones, R Ian Storer, Yogesh A Sabnis, et al.Cell Chemical Biology|March 7, 2017
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma CellsAnthony Tumber, Andrea Nuzzi, Edward S Hookway, et al.European Journal of Medicinal Chemistry|June 4, 2019
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assaysYann-Vaï Le Bihan, Rachel M Lanigan, Butrus Atrash, et al.Journal of Medicinal Chemistry|January 8, 2016
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsVassilios Bavetsias, Rachel M Lanigan, Gian Filippo Ruda, et al.Pageof 1