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Antimicrobial Agents and Chemotherapy|November 24, 2005
Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1Julie M Strizki, Cecile Tremblay, Serena Xu, et al.Journal of Medicinal Chemistry|November 3, 2018
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine MoietyMihirbaran Mandal, Kaushik Mitra, Diane Grotz, et al.Bioorganic & Medicinal Chemistry Letters|March 7, 2012
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitorJared N Cumming, Elizabeth M Smith, Lingyan Wang, et al.Journal of Medicinal Chemistry|September 20, 2012
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformationMihirbaran Mandal, Zhaoning Zhu, Jared N Cumming, et al.Science Translational Medicine|November 4, 2016
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patientsMatthew E Kennedy, Andrew W Stamford, Xia Chen, et al.ACS Medicinal Chemistry Letters|February 16, 2013
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ ReductionAndrew W Stamford, Jack D Scott, Sarah W Li, et al.Journal of Medicinal Chemistry|December 10, 2016
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's DiseaseJack D Scott, Sarah W Li, Andrew P J Brunskill, et al.Journal of Medicinal Chemistry|February 18, 2014
The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonistDuane DeMong, Xing Dai, Joyce Hwa, et al.Journal of Medicinal Chemistry|March 4, 2016
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman PrimatesMihirbaran Mandal, Yusheng Wu, Jeffrey Misiaszek, et al.ACS Medicinal Chemistry Letters|July 24, 2018
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for OncologySobhana Babu Boga, Yongqi Deng, Liang Zhu, et al.Pageof 3