Showing results (1-10 of 8) with videos related to
Sort By:
Pageof 1
Archives of Biochemistry and Biophysics|November 22, 2022
Expression and kinetic characterization of PYCR3Kaylen R Meeks, John J TannerProtein Science : a Publication of the Protein Society|August 12, 2024
Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)Kaylen R Meeks, Alexandra N Bogner, John J TannerMolecules (Basel, Switzerland)|November 27, 2024
Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde DehydrogenaseKaylen R Meeks, Alexandra N Bogner, Jay C Nix, et al.ACS Omega|January 30, 2023
Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1Oseeyi I Daudu, Kaylen R Meeks, Lu Zhang, et al.ACS Chemical Biology|April 21, 2026
Targeting a Unique Cysteine Residue to Achieve Isoform-Selective Inhibition of the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 2Tyrell C Rossman, Kaylen R Meeks, Gunjan Purohit, et al.Journal of Chemical Information and Modeling|February 27, 2024
Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray CrystallographyKaylen R Meeks, Juan Ji, Mykola V Protopopov, et al.The Biochemical Journal|January 22, 2026
Serendipitous Discovery of an Allosteric Inhibitor Binding Groove in the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 1 (PYCR1)Kaylen R Meeks, Caitlin J Mattingly, Jay C Nix, et al.Archives of Biochemistry and Biophysics|January 27, 2025
Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenaseKaylen R Meeks, Juan Ji, Gary K Scott, et al.Pageof 1