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Molecular Genetics and Metabolism|February 3, 2009
Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry diseaseKanako Sugawara, Youichi Tajima, Ikuo Kawashima, et al.
Molecular Genetics and Metabolism|June 2, 2016
Molecular diagnosis of 65 families with mucopolysaccharidosis type II (Hunter syndrome) characterized by 16 novel mutations in the IDS gene: Genetic, pathological, and structural studies on iduronate-2-sulfataseMotomichi Kosuga, Ryuichi Mashima, Asami Hirakiyama, et al.
Journal of Medicinal Chemistry|August 22, 2012
Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitorToru Asano, Hitoshi Yamazaki, Chiyoshi Kasahara, et al.
Molecular Genetics and Metabolism|July 31, 2012
Mutant α-galactosidase A with M296I does not cause elevation of the plasma globotriaosylsphingosine levelSayuri Mitobe, Tadayasu Togawa, Takahiro Tsukimura, et al.
ACS Omega|July 31, 2023
Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray CrystallographyRyunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, et al.
Bioorganic & Medicinal Chemistry|July 22, 2009
Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonistsIppei Sato, Koichiro Morihira, Hiroshi Inami, et al.
Scientific Reports|July 29, 2017
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas diseaseRyunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, et al.
American Journal of Human Genetics|October 27, 2009
Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry diseaseYouichi Tajima, Ikuo Kawashima, Takahiro Tsukimura, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 8, 2011
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)Naoki Numajiri, Kumi Takasawa, Tadashi Nishiya, et al.
Biochemical and Biophysical Research Communications|December 7, 2010
Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptorKazuki Ohno, Yasushi Amano, Hirotoshi Kakuta, et al.
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