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Signal Transduction and Targeted Therapy|February 19, 2021
Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activityKe-Wu Zeng, Jing-Kang Wang, Li-Chao Wang, et al.
Ebiomedicine|August 16, 2017
Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation InhibitionLi-Chao Wang, Li-Xi Liao, Hai-Ning Lv, et al.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|April 23, 2023
Allosteric Activation of Transglutaminase 2 via Inducing an "Open" Conformation for Osteoblast DifferentiationZhuo Yang, Xiao-Wen Zhang, Fang-Fang Zhuo, et al.
Protein & Cell|September 10, 2024
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immuneMei-Mei Zhao, Ting-Ting Ren, Jing-Kang Wang, et al.
ACS Nano|February 9, 2026
In Situ Redox-Omics Decoding of Nanoparticle-Protein Corona Interactions Drives the Mitochondrial Metabolic-Immunological Mechanism in MicrogliaZe-Kun Chen, Ming Yu, Zhong-Yao Li, et al.
International Journal of Biological Sciences|May 19, 2025
Integrated thermal proteome and thermal proximity co-aggregation profiling identifies ATP6V1C1 as a novel anti-cancer drug targetShuang Zhang, Feng-Ming Li, Jun Wang, et al.
Science Advances|August 10, 2022
Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapyXiao-Wen Zhang, Na Feng, Yan-Chen Liu, et al.
Pharmacological Research|January 10, 2022
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modificationQiang Guo, Yi-Chi Zhang, Wei Wang, et al.
European Journal of Medicinal Chemistry|May 6, 2025
Discovery of sinomenine derivatives inhibiting macrophage polarization against rheumatoid arthritis through selectively targeting heme oxygenase-1Yong-Zhe Zheng, Yao Kong, Fang-Fang Zhuo, et al.
Theranostics|January 7, 2020
Allosteric regulation of protein 14-3-3ζ scaffold by small-molecule editing modulates histone H3 post-translational modificationsYan-Jun Wan, Li-Xi Liao, Yang Liu, et al.
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