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Applied Microbiology and Biotechnology|May 7, 2026
One-step in vivo assembly of a 63 kb-long biosynthetic gene cluster via multiple recombination in Aspergillus oryzaeKoichi Tamano, Haruka Takayama, Ikuko Kozone, et al.
Bioscience, Biotechnology, and Biochemistry|February 16, 2021
A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900Reiko Ueoka, Junko Hashimoto, Ikuko Kozone, et al.
Chemical & Pharmaceutical Bulletin|May 15, 2024
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene ClusterTakehiro Nishimura, Kei Kudo, Miho Izumikawa, et al.
Japanese Journal of Clinical Oncology|January 21, 2025
Breast cancer surveillance for epithelial ovarian cancer patients with BRCA1 and BRCA2 pathogenic variants: a single-center retrospective studyJunko Hasegawa-Minato, Mikako Tochigi, Shuko Miyahara, et al.
The Journal of Antibiotics|March 4, 2024
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compoundsKei Kudo, Takehiro Nishimura, Miho Izumikawa, et al.
Chemical Science|April 7, 2025
Biosynthesis of the tetrahydroxynaphthalene-derived meroterpenoid furaquinocin via reductive deamination and intramolecular hydroalkoxylation of an alkeneTomohiro Noguchi, Fan Zhao, Yoshitaka Moriwaki, et al.
Nature Communications|August 13, 2020
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivativesKei Kudo, Takuya Hashimoto, Junko Hashimoto, et al.
Chemical Science|January 7, 2026
Characterization of the ketoreductase domain of pikromycin module 2Eiji Okamura, Kosuke Ohsawa, Hidetoshi Ban, et al.
FEBS Letters|January 18, 2020
Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancerKei Kudo, Miyuki Nomura, Yoshimi Sakamoto, et al.
Cancer Gene Therapy|February 29, 2024
Dual-inhibition of NAMPT and PAK4 induces anti-tumor effects in 3D-spheroids model of platinum-resistant ovarian cancerKei Kudo, Yoshimi Endo Greer, Teruhiko Yoshida, et al.
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