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Cancer Research|November 29, 2017
Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast CancerJason P W Carey, Cansu Karakas, Tuyen Bui, et al.Scientific Reports|February 14, 2019
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor modelsZebin Wang, Kaiming Sun, Yonghong Xiao, et al.ACS Chemical Biology|July 31, 2013
Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1Jiaquan Wu, Keith Mikule, Wenxian Wang, et al.Journal of Medicinal Chemistry|December 3, 2014
Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screeningBin Yang, Michelle L Lamb, Tao Zhang, et al.Bioorganic & Medicinal Chemistry Letters|September 1, 2016
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clusteringChungang Gu, Michelle L Lamb, Jeffrey W Johannes, et al.Cancer Research|October 10, 2018
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast CancerZebin Wang, Shaun E Grosskurth, Tony Cheung, et al.Bioorganic & Medicinal Chemistry Letters|November 8, 2015
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clusteringJeffrey W Johannes, Lynsie Almeida, Kevin Daly, et al.Journal of Medicinal Chemistry|August 14, 2020
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1RBarbara Czako, Joseph R Marszalek, Jason P Burke, et al.Journal of Medicinal Chemistry|July 22, 2021
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) ApoenzymeMatthew M Hamilton, Faika Mseeh, Timothy J McAfoos, et al.Pageof 2