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Bioorganic & Medicinal Chemistry Letters|March 31, 2007
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoproteinChristopher D Cox, Michael J Breslin, David B Whitman, et al.
Bioorganic & Medicinal Chemistry Letters|September 4, 2007
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSPAnthony J Roecker, Paul J Coleman, Swati P Mercer, et al.
Bioorganic & Medicinal Chemistry Letters|April 11, 2006
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSPChristopher D Cox, Maricel Torrent, Michael J Breslin, et al.
Molecular Cancer Therapeutics|December 14, 2002
Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-IRobert B Lobell, Dongming Liu, Carolyn A Buser, et al.
Bioorganic & Medicinal Chemistry Letters|September 23, 2006
Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitorsShaei Huang, Robert M Garbaccio, Mark E Fraley, et al.
Bioorganic & Medicinal Chemistry Letters|January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSPMark E Fraley, Robert M Garbaccio, Kenneth L Arrington, et al.
Bioorganic & Medicinal Chemistry Letters|January 22, 2009
Development of thioquinazolinones, allosteric Chk1 kinase inhibitorsAntonella Converso, Timothy Hartingh, Robert M Garbaccio, et al.
Bioorganic & Medicinal Chemistry Letters|September 1, 2007
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSPPaul J Coleman, John D Schreier, Christopher D Cox, et al.
Bioorganic & Medicinal Chemistry Letters|January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubilityRobert M Garbaccio, Mark E Fraley, Edward S Tasber, et al.
Bioorganic & Medicinal Chemistry Letters|September 19, 2006
3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6Mark E Fraley, Justin T Steen, Edward J Brnardic, et al.
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