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Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 27, 2026
Combining the novel all-human co-cultured hepatocytes system with physiologically based pharmacokinetic modeling to assess the translatability of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase induction dataAlessandra Pugliano, Aynur Ekiciler, Neil John Parrott, et al.
Drug Metabolism and Personalized Therapy|May 31, 2019
Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissionsKenichi Umehara, Felix Huth, Yi Jin, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|January 15, 2026
Fraction metabolized by cytochrome P450 enzymes: A comprehensive evaluation of the translatability of an in vitro HepatoPac assayFlorian Klammers, Thanusa Shanmugalingam, Tobias Remus, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 5, 2022
Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human HepatocytesFlorian Klammers, Andreas Goetschi, Aynur Ekiciler, et al.
Drug Metabolism and Pharmacokinetics|January 7, 2026
Current status of prediction of IL-6 mediated cytochrome P450 activity modulation using in vitro data and PBPK modelingViktor Georgiev, Isabelle Anderka, Delia Bucher, et al.
Clinical Pharmacokinetics|June 16, 2023
The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver CirrhosisUrs Duthaler, Fabio Bachmann, Agustos C Ozbey, et al.
Molecular Pharmaceutics|July 8, 2026
Predicting First-in-Human Pharmacokinetics: Comparative Evaluation of Standard PBPK, High-Throughput PBPK, and Machine LearningSilvan Käser, Davide Bassani, Neil John Parrott, et al.
Clinical Pharmacokinetics|February 11, 2025
Clinical Exploration and Physiologically Based Modelling of the Impact of Hepatic Impairment on Entrectinib PharmacokineticsAgustos C Ozbey, Georgina Meneses-Lorente, Brian Simmons, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|December 2, 2022
Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating ProfilesAynur Ekiciler, Wen Li Kelly Chen, Yan Bo, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 5, 2025
CYP1A2 contributes to the metabolism of mefloquine: Exploration using in vitro metabolism and physiologically-based pharmacokinetic modellingCleavon K Cloete, Preshendren Govender, Nicholas Njuguna, et al.
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