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Cancer Chemotherapy and Pharmacology|July 21, 2019
Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjectsVassilios Aslanis, Kenichi Umehara, Felix Huth, et al.
Journal of Pharmaceutical Sciences|June 17, 2026
A framework for plasma protein binding: Comparing methods for diverse small molecules and adapting for novel modalitiesZachary Enlo-Scott, Victor Dudal, Maja Gredelj, et al.
Clinical Pharmacology and Therapeutics|April 5, 2023
Dose Adjustment in Patients with Liver Cirrhosis - Comparison of Two Different Modeling ApproachesAgustos C Ozbey, Fabio Bachmann, Urs Duthaler, et al.
The AAPS Journal|November 6, 2020
Correction to: In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human HepatocytesLuca Docci, Florian Klammers, Aynur Ekiciler, et al.
The AAPS Journal|October 14, 2020
In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human HepatocytesLuca Docci, Florian Klammers, Aynur Ekiciler, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems|September 8, 2017
Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in ratYildiz Yilmaz, Kenichi Umehara, Gareth Williams, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 23, 2024
Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with MidazolamAgustos C Ozbey, Janneke Keemink, Bjoern Wagner, et al.
Clinical Pharmacology and Therapeutics|January 12, 2023
Industry Perspective on Therapeutic Peptide Drug-Drug Interaction Assessments During Drug Development: A European Federation of Pharmaceutical Industries and Associations White PaperCarolina Säll, Upendra Argikar, Kari Fonseca, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 3, 2020
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance PredictionKenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, et al.
Pharmaceutics|September 28, 2023
Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell BindingMatthias Van der Veken, Joachim Brouwers, Agustos Cetin Ozbey, et al.
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