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Bioorganic & Medicinal Chemistry Letters|May 18, 2007
Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain modelArthur Gomtsyan, Erol K Bayburt, Ryan Keddy, et al.Bioorganic & Medicinal Chemistry Letters|May 25, 2005
Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesityAndrew J Souers, Ju Gao, Dariusz Wodka, et al.Cancer Research|May 3, 2008
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitorChristin Tse, Alexander R Shoemaker, Jessica Adickes, et al.Journal of Medicinal Chemistry|October 10, 2008
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteinsCheol-Min Park, Milan Bruncko, Jessica Adickes, et al.Journal of Medicinal Chemistry|January 16, 2009
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancerThomas D Penning, Gui-Dong Zhu, Viraj B Gandhi, et al.Pharmacology, Biochemistry, and Behavior|December 17, 2009
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in ratsGin C Hsieh, Prasant Chandran, Anita K Salyers, et al.Bioorganic & Medicinal Chemistry|January 2, 2007
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitorsMark A Matulenko, Ernest S Paight, Robin R Frey, et al.Bioorganic & Medicinal Chemistry Letters|January 13, 2006
Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluationQun Li, Tongmei Li, Gui-Dong Zhu, et al.Bioorganic & Medicinal Chemistry Letters|October 6, 2005
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonistsAnil Vasudevan, Andrew J Souers, Jennifer C Freeman, et al.Journal of Medicinal Chemistry|September 27, 2008
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation modelsMarlon D Cowart, Robert J Altenbach, Huaqing Liu, et al.Pageof 11