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Journal of Medicinal Chemistry|November 6, 2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesiaHuaqing Liu, Robert J Altenbach, Tracy L Carr, et al.Bioorganic & Medicinal Chemistry|May 26, 2012
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²⁺ channel blockers with analgesic activityXenia Beebe, Daria Darczak, Rodger F Henry, et al.Journal of Medicinal Chemistry|June 23, 2007
In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonistsRichard J Perner, Stanley DiDomenico, John R Koenig, et al.Journal of Medicinal Chemistry|June 10, 2005
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitorsClarence J Maring, Vincent S Stoll, Chen Zhao, et al.Journal of Medicinal Chemistry|April 15, 2005
Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activitiesFortuna Haviv, Michael F Bradley, Douglas M Kalvin, et al.Journal of Medicinal Chemistry|March 28, 2009
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effectsDavid A Degoey, David J Grampovnik, Charles A Flentge, et al.Bioorganic & Medicinal Chemistry|April 20, 2006
Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonistsIrene Drizin, Arthur Gomtsyan, Erol K Bayburt, et al.Journal of Medicinal Chemistry|March 27, 2010
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitorThomas D Penning, Gui-Dong Zhu, Jianchun Gong, et al.Bioorganic & Medicinal Chemistry|June 11, 2008
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancerThomas D Penning, Gui-Dong Zhu, Viraj B Gandhi, et al.Journal of Medicinal Chemistry|August 18, 2006
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunctionTeodozyj Kolasa, Mark A Matulenko, Ahmed A Hakeem, et al.Pageof 11