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Biochemistry
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June 14, 2006
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
Kenton L Longenecker, Kent D Stewart, David J Madar, et al.
Chemical Biology & Drug Design
|
February 24, 2006
Structure-based optimization of MurF inhibitors
Geoffrey F Stamper, Kenton L Longenecker, Elizabeth H Fry, et al.
ACS Medicinal Chemistry Letters
|
July 16, 2021
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors
Yunsong Tong, Alan S Florjancic, Rick F Clark, et al.
Journal of Medicinal Chemistry
|
July 9, 2025
Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators
Zhiguo Bian, Robert G Schmidt, Noel S Wilson, et al.
ACS Chemical Biology
|
February 21, 2022
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy
Sven Malchow, Alla Korepanova, Sanjay C Panchal, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 14, 2013
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
A Chris Krueger, John T Randolph, David A DeGoey, et al.
Journal of Medicinal Chemistry
|
January 18, 2018
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability
John T Randolph, A Chris Krueger, Pamela L Donner, et al.
Journal of Medicinal Chemistry
|
December 30, 2020
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Justin D Dietrich, Kenton L Longenecker, Noel S Wilson, et al.
Science Translational Medicine
|
March 20, 2024
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases
Michael J McPherson, Adrian D Hobson, Axel Hernandez, et al.
Journal of Medicinal Chemistry
|
October 13, 2006
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
David J Madar, Hana Kopecka, Daisy Pireh, et al.
Page
of 3
Search research articles
Search
Showing results (11-20 of 22) with videos related to
Sort By:
Page
of 3
Biochemistry
|
June 14, 2006
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
Kenton L Longenecker, Kent D Stewart, David J Madar, et al.
Chemical Biology & Drug Design
|
February 24, 2006
Structure-based optimization of MurF inhibitors
Geoffrey F Stamper, Kenton L Longenecker, Elizabeth H Fry, et al.
ACS Medicinal Chemistry Letters
|
July 16, 2021
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors
Yunsong Tong, Alan S Florjancic, Rick F Clark, et al.
Journal of Medicinal Chemistry
|
July 9, 2025
Discovery of Orally Efficacious Bridged Piperazines as smTNF Modulators
Zhiguo Bian, Robert G Schmidt, Noel S Wilson, et al.
ACS Chemical Biology
|
February 21, 2022
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy
Sven Malchow, Alla Korepanova, Sanjay C Panchal, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 14, 2013
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
A Chris Krueger, John T Randolph, David A DeGoey, et al.
Journal of Medicinal Chemistry
|
January 18, 2018
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability
John T Randolph, A Chris Krueger, Pamela L Donner, et al.
Journal of Medicinal Chemistry
|
December 30, 2020
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Justin D Dietrich, Kenton L Longenecker, Noel S Wilson, et al.
Science Translational Medicine
|
March 20, 2024
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases
Michael J McPherson, Adrian D Hobson, Axel Hernandez, et al.
Journal of Medicinal Chemistry
|
October 13, 2006
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
David J Madar, Hana Kopecka, Daisy Pireh, et al.
Page
of 3