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Journal of the American Chemical Society|July 1, 2024
On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to TherapyPragya Adhikari, Guangmin Li, MaryAnn Go, et al.Neuron|November 5, 2020
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion ChannelChang Liu, Rebecca Reese, Simon Vu, et al.Journal of Medicinal Chemistry|July 20, 2016
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung CancersGérald Lelais, Robert Epple, Thomas H Marsilje, et al.Journal of Medicinal Chemistry|March 27, 2014
Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacyDean P Phillips, Wenqi Gao, Yang Yang, et al.Journal of Medicinal Chemistry|November 21, 2017
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic PropertiesTony Siu, Jason Brubaker, Peter Fuller, et al.Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association|November 17, 2025
In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217Summan Zahra, Scott R French, Juan C Arias, et al.Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences|January 7, 2020
Mariana serpentinite mud volcanism exhumes subducted seamount materials: implications for the origin of lifePatricia Fryer, C Geoffrey Wheat, Trevor Williams, et al.Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association|August 7, 2025
Cognitive impairment and p-tau217 are high in a vascular patient cohortScott R French, Juan C Arias, Summan Zahra, et al.Journal of Medicinal Chemistry|June 8, 2013
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trialsThomas H Marsilje, Wei Pei, Bei Chen, et al.Journal of Medicinal Chemistry|March 22, 2021
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron MicroscopyJack A Terrett, Huifen Chen, Daniel G Shore, et al.Pageof 20