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ACS Medicinal Chemistry Letters|March 19, 2020
New Chemical Modalities and Strategic Thinking in Early Drug DiscoveryMaria-Jesus Blanco, Kevin M GardinierACS Medicinal Chemistry Letters|November 17, 2022
Advancing New Chemical Modalities into Clinical StudiesMaria-Jesus Blanco, Kevin M Gardinier, Mark N NamchukJournal of Neurochemistry|May 25, 2016
Reconstitution of synaptic Ion channels from rodent and human brain in Xenopus oocytes: a biochemical and electrophysiological characterizationFrancesca Mazzo, Ruud Zwart, Giulia Maia Serratto, et al.ACS Chemical Neuroscience|August 22, 2017
Structural Determinants of the γ-8 TARP Dependent AMPA Receptor AntagonistMatthew R Lee, Kevin M Gardinier, Douglas L Gernert, et al.CNS & Neurological Disorders Drug Targets|November 2, 2017
Targeted Blockade of TARP-γ8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611)Jeffrey M Witkin, Douglas A Schober, Scott D Gleason, et al.Neuropharmacology|August 1, 2017
Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptorsJeffrey M Witkin, Jennifer Li, Gary Gilmour, et al.ACS Medicinal Chemistry Letters|December 20, 2023
Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 AgonistsChristopher G Thomson, Kelly Boss, Amy Calhoun, et al.The Journal of Pharmacology and Experimental Therapeutics|March 27, 2019
Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic PainKelly L Knopp, Rosa Maria A Simmons, Wenhong Guo, et al.Nature Medicine|November 8, 2016
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanismAkihiko S Kato, Kevin D Burris, Kevin M Gardinier, et al.Journal of Medicinal Chemistry|April 13, 2016
Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8Kevin M Gardinier, Douglas L Gernert, Warren J Porter, et al.Pageof 2