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Nature Communications|September 3, 2021
The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TBSchara Safarian, Helen K Opel-Reading, Di Wu, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 28, 2017
Exploiting the synthetic lethality between terminal respiratory oxidases to kill <i>Mycobacterium tuberculosis</i> and clear host infectionNitin P Kalia, Erik J Hasenoehrl, Nurlilah B Ab Rahman, et al.
ACS Medicinal Chemistry Letters|October 20, 2022
Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of <i>Mycobacterium tuberculosis</i> Cytochrome <i>bd</i> OxidaseAggie Lawer, Chelsea Tyler, Kiel Hards, et al.
Scientific Reports|November 16, 2019
Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesisWuan-Geok Saw, Mu-Lu Wu, Priya Ragunathan, et al.
Msphere|March 20, 2020
Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2Nichaela Harbison-Price, Scott A Ferguson, Adam Heikal, et al.
ACS Infectious Diseases|November 29, 2018
Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant TuberculosisXiaoyun Lu, Zoe Williams, Kiel Hards, et al.
European Journal of Medicinal Chemistry|June 12, 2020
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptorsMaria Giulia Nizi, Jenny Desantis, Yoshio Nakatani, et al.
Plos Pathogens|February 8, 2020
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineeringBrendon M Lee, Liam K Harold, Deepak V Almeida, et al.
Cell Chemical Biology|December 27, 2023
A dual-targeting succinate dehydrogenase and F<sub>1</sub>F<sub>o</sub>-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosisCara Adolph, Chen-Yi Cheung, Matthew B McNeil, et al.
EMBO Molecular Medicine|December 7, 2020
Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosisBei Shi Lee, Kiel Hards, Curtis A Engelhart, et al.
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