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Brain : a Journal of Neurology|October 16, 2025
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease modelsEduardo A Albornoz, Karine Mardon, Rajiv Bhalla, et al.Journal of Medicinal Chemistry|July 11, 2022
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's DiseaseTammy Ladduwahetty, Matthew R Lee, Michel C Maillard, et al.Journal of Medicinal Chemistry|September 13, 2022
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease PathologyNatsuko Macabuag, William Esmieu, Perla Breccia, et al.Journal of Medicinal Chemistry|November 25, 2024
Novel Macrocyclic NLRP3 InhibitorsStefanie Mesch, Jonathan Shannon, David Miller, et al.Neuropharmacology|November 14, 2022
Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasomeBernardino Ossola, Ali Rifat, Anna Rowland, et al.Journal of Medicinal Chemistry|March 12, 2015
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitorsJohn Wityak, Kevin F McGee, Michael P Conlon, et al.Pageof 2