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ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of MigraineGuanglin Luo, Ling Chen, Charles M Conway, et al.Journal of Medicinal Chemistry|November 17, 2012
Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraineGuanglin Luo, Ling Chen, Charles M Conway, et al.Toxicological Sciences : an Official Journal of the Society of Toxicology|June 1, 2023
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulatorXiaoliang Zhuo, Brett A Howell, Hong Shen, et al.Bioorganic & Medicinal Chemistry Letters|July 26, 2011
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Jianliang Shi, et al.Bioorganic & Medicinal Chemistry Letters|October 27, 2015
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Yong-Jin Wu, et al.The Journal of Pharmacology and Experimental Therapeutics|May 19, 2016
The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy VolunteersHolly D Soares, Maciej Gasior, Jeremy H Toyn, et al.Journal of Medicinal Chemistry|October 4, 2012
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesisSamuel W Gerritz, Weixu Zhai, Shuhao Shi, et al.The Journal of Pharmacology and Experimental Therapeutics|May 24, 2008
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in miceJere E Meredith, Lorin A Thompson, Jeremy H Toyn, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase InhibitorKevin W Gillman, John E Starrett, Michael F Parker, et al.Journal of Medicinal Chemistry|June 26, 2009
In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonistsRichard A Hartz, Vijay T Ahuja, Maria Rafalski, et al.Pageof 4