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Nature Communications|July 15, 2024
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy modelsHenri Leinonen, Jianye Zhang, Laurence M Occelli, et al.Bioorganic & Medicinal Chemistry Letters|April 27, 2023
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug designJames J Crawford, Jianwen Feng, Hans D Brightbill, et al.Journal of Medicinal Chemistry|May 14, 2013
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activityChudi O Ndubaku, Timothy P Heffron, Steven T Staben, et al.Journal of Medicinal Chemistry|January 8, 2016
The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)Timothy P Heffron, Robert A Heald, Chudi Ndubaku, et al.Bioorganic & Medicinal Chemistry Letters|April 2, 2013
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoformSteven T Staben, Chudi Ndubaku, Nicole Blaquiere, et al.Nature Biotechnology|August 14, 2019
Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genomeAaron M Wenger, Paul Peluso, William J Rowell, et al.Biorxiv : the Preprint Server for Biology|September 4, 2024
DeepSomatic: Accurate somatic small variant discovery for multiple sequencing technologiesJimin Park, Daniel E Cook, Pi-Chuan Chang, et al.Journal of Medicinal Chemistry|March 30, 2018
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular ModelingHuifen Chen, Matthew Volgraf, Steven Do, et al.Nature Biotechnology|March 29, 2022
Accelerated identification of disease-causing variants with ultra-rapid nanopore genome sequencingSneha D Goenka, John E Gorzynski, Kishwar Shafin, et al.Nucleic Acids Research|November 19, 2008
ArrayExpress update--from an archive of functional genomics experiments to the atlas of gene expressionHelen Parkinson, Misha Kapushesky, Nikolay Kolesnikov, et al.Pageof 119