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Cell Death & Disease|February 16, 2021
Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitorsKonstantinos V Floros, Sheeba Jacob, Richard Kurupi, et al.
Molecular Cell|December 9, 2014
Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosisThibaud T Renault, Konstantinos V Floros, Rana Elkholi, et al.
Biorxiv : the Preprint Server for Biology|February 27, 2026
Daraxonrasib (RMC-6236) is an effective targeted therapy for RAS -mutant neuroblastomaRonald D Hill, Krista M Dalton, Richard Kurupi, et al.
Science Translational Medicine|May 18, 2018
Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastomaTimothy L Lochmann, Krista M Powell, Jungoh Ham, et al.
Cancers|June 2, 2021
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXACarter K Fairchild, Konstantinos V Floros, Sheeba Jacob, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|October 24, 2018
The Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor ToxicityDaniel A R Heisey, Timothy L Lochmann, Konstantinos V Floros, et al.
Proceedings of the National Academy of Sciences of the United States of America|March 25, 2021
Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastomaKrista M Dalton, Timothy L Lochmann, Konstantinos V Floros, et al.
Cancer Research|January 23, 2021
MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione AxisKonstantinos V Floros, JinYang Cai, Sheeba Jacob, et al.
PNAS Nexus|January 30, 2023
Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer modelsSheeba Jacob, Tia H Turner, Jinyang Cai, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 10, 2017
Venetoclax Is Effective in Small-Cell Lung Cancers with High BCL-2 ExpressionTimothy L Lochmann, Konstantinos V Floros, Mitra Naseri, et al.
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