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The Journal of Organic Chemistry
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December 15, 2023
Fluorescent Rotary Switches: Four- vs Three-Substituted Phthalimide Boron Difluoride Schiff Base Complexes
Dancho Yordanov, Rastislav Smolka, Kosuke Nakashima, et al.
Journal of Medicinal Chemistry
|
August 1, 2017
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano, et al.
Journal of Labelled Compounds & Radiopharmaceuticals
|
April 21, 2015
Development of a series of novel carbon-11 labeled PDE10A inhibitors
Vladimir Stepanov, Shotaro Miura, Akihiro Takano, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
May 27, 2003
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents
Noriyuki Yamamoto, Keisuke Takeshita, Michitaka Shichijo, et al.
Bioorganic & Medicinal Chemistry
|
October 24, 2015
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo, et al.
Journal of Medicinal Chemistry
|
November 11, 2014
Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor
Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi, et al.
Biological & Pharmaceutical Bulletin
|
May 28, 2025
Systemic mRNA Delivery into the Muscle of Duchenne Muscular Dystrophy Model Mice Using Alpha-Dystroglycan Binding Peptide Modified Lipid Nanoparticles
Eri Sasaki, Yuki Itaya, Yoko Endo-Takahashi, et al.
Bioorganic & Medicinal Chemistry
|
January 20, 2022
Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity
Fumie Sakurai, Takafumi Yukawa, Asato Kina, et al.
Bioorganic & Medicinal Chemistry
|
January 14, 2023
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment
Takafumi Yukawa, Tohru Yamashita, Toshihiro Imaeda, et al.
Journal of Medicinal Chemistry
|
August 11, 2017
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
Satoshi Mikami, Shinji Nakamura, Tomoko Ashizawa, et al.
Page
of 6
Search research articles
Search
Showing results (41-50 of 52) with videos related to
Sort By:
Page
of 6
The Journal of Organic Chemistry
|
December 15, 2023
Fluorescent Rotary Switches: Four- vs Three-Substituted Phthalimide Boron Difluoride Schiff Base Complexes
Dancho Yordanov, Rastislav Smolka, Kosuke Nakashima, et al.
Journal of Medicinal Chemistry
|
August 1, 2017
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
Satoshi Mikami, Shigekazu Sasaki, Yasutomi Asano, et al.
Journal of Labelled Compounds & Radiopharmaceuticals
|
April 21, 2015
Development of a series of novel carbon-11 labeled PDE10A inhibitors
Vladimir Stepanov, Shotaro Miura, Akihiro Takano, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
May 27, 2003
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents
Noriyuki Yamamoto, Keisuke Takeshita, Michitaka Shichijo, et al.
Bioorganic & Medicinal Chemistry
|
October 24, 2015
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
Masato Yoshikawa, Haruhi Kamisaki, Jun Kunitomo, et al.
Journal of Medicinal Chemistry
|
November 11, 2014
Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor
Jun Kunitomo, Masato Yoshikawa, Makoto Fushimi, et al.
Biological & Pharmaceutical Bulletin
|
May 28, 2025
Systemic mRNA Delivery into the Muscle of Duchenne Muscular Dystrophy Model Mice Using Alpha-Dystroglycan Binding Peptide Modified Lipid Nanoparticles
Eri Sasaki, Yuki Itaya, Yoko Endo-Takahashi, et al.
Bioorganic & Medicinal Chemistry
|
January 20, 2022
Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity
Fumie Sakurai, Takafumi Yukawa, Asato Kina, et al.
Bioorganic & Medicinal Chemistry
|
January 14, 2023
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment
Takafumi Yukawa, Tohru Yamashita, Toshihiro Imaeda, et al.
Journal of Medicinal Chemistry
|
August 11, 2017
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
Satoshi Mikami, Shinji Nakamura, Tomoko Ashizawa, et al.
Page
of 6