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Kota Toshimoto

Showing results (1-10 of 23) with videos related to

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Drug Metabolism and Pharmacokinetics|June 4, 2024
Beyond the basics: A deep dive into parameter estimation for advanced PBPK and QSP modelsKota Toshimoto
Pharmaceutical Research|April 12, 2017
Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side EffectsKota Toshimoto, Atsuko Tomaru, Masakiyo Hosokawa, et al.
Journal of Pharmaceutical Sciences|May 9, 2017
Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug-Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be Recovered by the Analyses Using Physiologically Based Pharmacokinetic ModelingKota Toshimoto, Yukana Tomoda, Koji Chiba, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 9, 2021
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target OccupancySatoshi Koyama, Kota Toshimoto, Wooin Lee, et al.
CPT: Pharmacometrics & Systems Pharmacology|September 5, 2023
Physiologically-based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1BShinji Nakayama, Kota Toshimoto, Shinji Yamazaki, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 15, 2018
Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of RosuvastatinAzusa Futatsugi, Kota Toshimoto, Takashi Yoshikado, et al.
Journal of Pharmaceutical Sciences|November 2, 2020
A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A SaturationAtsuko Tomaru, Kota Toshimoto, Wooin Lee, et al.
Drug Metabolism and Pharmacokinetics|May 26, 2024
Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncologyMasayo Oishi, Hiroyuki Sayama, Kota Toshimoto, et al.
Journal of Pharmaceutical Sciences|May 9, 2017
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition DataSoo-Jin Kim, Kota Toshimoto, Yoshiaki Yao, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 2, 2018
Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic ModelingYoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, et al.
Pageof 3

Showing results (1-10 of 23) with videos related to

Sort By:
Pageof 3
Drug Metabolism and Pharmacokinetics|June 4, 2024
Beyond the basics: A deep dive into parameter estimation for advanced PBPK and QSP modelsKota Toshimoto
Pharmaceutical Research|April 12, 2017
Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side EffectsKota Toshimoto, Atsuko Tomaru, Masakiyo Hosokawa, et al.
Journal of Pharmaceutical Sciences|May 9, 2017
Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug-Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be Recovered by the Analyses Using Physiologically Based Pharmacokinetic ModelingKota Toshimoto, Yukana Tomoda, Koji Chiba, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 9, 2021
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target OccupancySatoshi Koyama, Kota Toshimoto, Wooin Lee, et al.
CPT: Pharmacometrics & Systems Pharmacology|September 5, 2023
Physiologically-based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1BShinji Nakayama, Kota Toshimoto, Shinji Yamazaki, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 15, 2018
Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of RosuvastatinAzusa Futatsugi, Kota Toshimoto, Takashi Yoshikado, et al.
Journal of Pharmaceutical Sciences|November 2, 2020
A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A SaturationAtsuko Tomaru, Kota Toshimoto, Wooin Lee, et al.
Drug Metabolism and Pharmacokinetics|May 26, 2024
Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncologyMasayo Oishi, Hiroyuki Sayama, Kota Toshimoto, et al.
Journal of Pharmaceutical Sciences|May 9, 2017
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition DataSoo-Jin Kim, Kota Toshimoto, Yoshiaki Yao, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 2, 2018
Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic ModelingYoshiaki Yao, Kota Toshimoto, Soo-Jin Kim, et al.
Pageof 3