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CPT: Pharmacometrics & Systems Pharmacology
|
March 2, 2019
Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine
Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, et al.
CPT: Pharmacometrics & Systems Pharmacology
|
June 20, 2018
Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen
Toshimichi Nakamura, Kota Toshimoto, Wooin Lee, et al.
Pharmaceutical Research
|
August 26, 2018
In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines
Naomi Wakayama, Kota Toshimoto, Kazuya Maeda, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
May 5, 2017
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
Takashi Yoshikado, Kota Toshimoto, Tomohisa Nakada, et al.
Journal of Pharmaceutical Sciences
|
October 15, 2020
Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B
Ji Eun Park, Yoshihisa Shitara, Wooin Lee, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
February 25, 2018
Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics
Masanobu Sato, Kota Toshimoto, Atsuko Tomaru, et al.
CPT: Pharmacometrics & Systems Pharmacology
|
January 26, 2018
Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug-Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects
Ryuta Asaumi, Kota Toshimoto, Yoshifusa Tobe, et al.
CPT: Pharmacometrics & Systems Pharmacology
|
September 4, 2018
PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3
Takashi Yoshikado, Kota Toshimoto, Kazuya Maeda, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|
October 6, 2018
Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake
Ryo Fujino, Kenta Hashizume, Shinsuke Aoyama, et al.
Journal of Pharmaceutical Sciences
|
June 6, 2016
Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure
Atsushi Ose, Kota Toshimoto, Kazushi Ikeda, et al.
Page
of 3
Search research articles
Search
Showing results (11-20 of 23) with videos related to
Sort By:
Page
of 3
CPT: Pharmacometrics & Systems Pharmacology
|
March 2, 2019
Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine
Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, et al.
CPT: Pharmacometrics & Systems Pharmacology
|
June 20, 2018
Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen
Toshimichi Nakamura, Kota Toshimoto, Wooin Lee, et al.
Pharmaceutical Research
|
August 26, 2018
In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines
Naomi Wakayama, Kota Toshimoto, Kazuya Maeda, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
May 5, 2017
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
Takashi Yoshikado, Kota Toshimoto, Tomohisa Nakada, et al.
Journal of Pharmaceutical Sciences
|
October 15, 2020
Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B
Ji Eun Park, Yoshihisa Shitara, Wooin Lee, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
February 25, 2018
Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics
Masanobu Sato, Kota Toshimoto, Atsuko Tomaru, et al.
CPT: Pharmacometrics & Systems Pharmacology
|
January 26, 2018
Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug-Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects
Ryuta Asaumi, Kota Toshimoto, Yoshifusa Tobe, et al.
CPT: Pharmacometrics & Systems Pharmacology
|
September 4, 2018
PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3
Takashi Yoshikado, Kota Toshimoto, Kazuya Maeda, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|
October 6, 2018
Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake
Ryo Fujino, Kenta Hashizume, Shinsuke Aoyama, et al.
Journal of Pharmaceutical Sciences
|
June 6, 2016
Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure
Atsushi Ose, Kota Toshimoto, Kazushi Ikeda, et al.
Page
of 3